Lily-Rose Melody Depp was born in Paris on May 27, 1999. She is the daughter of American actor, producer, and musician Johnny Depp and French singer/actress Vanessa Paradis. After 14 years together, her parents split in 2012 and set up shared joint custody of Depp, who splits her time between Los Angeles and Paris. Lily-Rose is the older sister of John « Jack » Christopher Depp III and the niece of French actress Alysson Paradis.

Lily-Rose began her acting career with a cameo role in Tusk, which premiered at the Toronto International Film Festival in September 2014. She acted alongside her friend Harley Quinn Smith, her father, and the film’s director Kevin Smith. In April 2015, Lily-Rose posed for a photo-shoot in the Australian magazine Oyster by Dana Boulos and Maggie Silverman. She was announced as a Chanel ambassador in September and modeled for the brand’s eyewear line. Lily-Rose appears with Irish rapper Rejjie Snow in his video for « All Around the World », which was released in October.

Lily-Rose reprised her Tusk role in Yoga Hosers, a spin-off that focuses on her and Harley Quinn Smith’s characters, and premiered at the Sundance Film Festival in January 2016. In May, she was announced as the face of Chanel’s new fragrance No°5 L’Eau. That same month, The Dancer, in which Lily-Rose plays Isadora Duncan, premiered at the Cannes Film Festival in the Un Certain Regard category. The film is Stéphanie Di Giusto’s directorial debut. Lily-Rose and Natalie Portman co-starred in Rebecca Zlotowski’s Planetarium as two spiritualist sisters in 1930s France. The film had its premiere at the Venice Film Festival in September. Lily-Rose appeared on the front cover of British Vogue in their December issue. In 2017, still Chanel’s muse, she became the new face of the ‘ Rouge Coco Gloss’ cosmetic collection, a campaign her mother also did when she was a young face of the brand ! And since July 2017, she’s also on display for the new collection ‘Airspace Fall collection’ alongside model Cara Delevingne.

In August 2015, Lily-Rose posed for iO Tillett Wright’s Self-Evident Truths Project, stating she falls somewhere on the LGBT spectrum. Although being too young to vote, she supported Bernie Sanders during the 2016 presidential election. Lily-Rose and her mother Vanessa Paradis were photographed for Our City of Angels magazine in February 2017. The sales proceeds for the issue will be donated to Planned Parenthood.